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These putative effects can be taken in context of a wide range of cardiovascular phenomena regulated by the endocannabinoid system and an overall role of cannabis in causing decreased peripheral resistance and increased cardiac output, which potentially could pose a threat to those with cardiovascular disease.Cannabis usually causes no tolerance or withdrawal symptoms except in heavy users.Although cannabis remains prohibited for any use at the federal level, the Rohrabacher–Farr amendment was enacted in December 2014, limiting the ability of federal law to be enforced in states where medical cannabis has been legalized.Many different cannabis strains are collectively called medical cannabis.The drug use must be "implicated" in the emergency department visit, but does not need to be the direct cause of the visit.Most of the illicit drug emergency room visits involved multiple drugs.There is serious suspicion among cardiologists, spurring research but falling short of definitive proof, that cannabis use has the potential to contribute to cardiovascular disease.Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation.

Combustion products are not present when using a vaporizer, consuming THC in pill form, or consuming cannabis edibles.According to the United States Department of Health and Human Services, there were 455,000 emergency room visits associated with cannabis use in 2011.These statistics include visits in which the patient was treated for a condition induced by or related to recent cannabis use.Tolerance to these effects develops over a period of days or weeks.The amount of cannabis normally used for medicinal purposes is not believed to cause any permanent cognitive impairment in adults, though long-term treatment in adolescents should be weighed carefully as they are more susceptible to these impairments.

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