Least sedating benzodiazepine

Oral versions of scopolamine would seem equally likely to work as patches (e.g.oral drugs for IBS) for motion sickness, but there currently is no oral version of scopolamine (hyoscine).

Unfortunately, astemizole does not appear to be generally useful as it is ineffective in preventing motion sickness (Kohl et al, 1987) and because it has significant potential toxicity.Hyoscyamine, which is the L-isomer of atropine, is a common ingrediant in antispasmodic treatments for IBS.Hyoscine, or scopolamine, is mainly used in the patch form to prevent motion sickness.Scopolamine and atropine are nonspecific muscarinic receptor antagonists (Barton et al, 1994; Soto et al, 2013).Diphenidol (Vontrol), is also an anticholinergic, although little used in the US.

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